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Controlled Perfusion of 3D Tumor Models

Stable perfusion platform for 3D tumor models. Learn how A4BEE enabled precise nanoparticle analysis using modular QB Systems.

Industry

Biotechnology / Academic Research / Nanomedicine / Preclinical Research

Scope

Hardware Delivery / Modular Integration / Bio-modeling

Timeframe

2025 – ongoing collaboration

Technology

  • QB Systems EDGE Main Unit
  • QB Peristaltic Pump Modules
  • QB Pressure Sensor Module
  • Custom 3D-printed perfusion chamber
  • Fluorescence-based imaging system
  • QB Control

4

operators onboarded (team usage)

3

months design to delivery (fast time-to-market)

<5 min

setup time (rapid deployment)

The client

A leading European academic research group working in the field of nanomaterials, bioprinting, 3D tumor models, and advanced drug delivery research. The team develops 3D-printed tumor-mimicking hydrogels with embedded perfusion channels and uses fluorescence-based analysis to investigate how nanoparticles penetrate from a vessel-like channel into the surrounding extracellular matrix (ECM).

Business needs

The research team required a stable and reproducible perfusion platform that would:

The priority was to maintain consistent, repeatable process parameters, ensuring the technical setup supports the full complexity of the biological experiments.

The challenge

  • 01

    Physiological Perfusion Reproducing physiologically relevant, stable perfusion within soft 3D-printed hydrogel tumor models.

  • 02

    Continuous Flow Maintaining controlled, continuous unidirectional flow without disrupting the experimental structure.

  • 03

    Workflow Integration Integrating the perfusion platform with custom chambers and fluorescence imaging workflows.

Our solution

A4BEE delivered and configured a modular QB Systems setup consisting of EDGE main unit, two QB peristaltic pumps, QB pressure sensor module, and a custom Perfusion chamber. The solution entailed:

  1. Hardware Configuration

    Delivery and configuration of QB Systems perfusion hardware.

  2. Process Control

    Setup of unidirectional constant flow operation and pressure fluctuations monitoring.

  3. System Integration

    Integration with the client’s custom 3D-printed perfusion chamber.

  4. Remote Support

    Secure VPN configuration for remote updates and support.

Technology used

  • QB Systems EDGE Main Unit
  • QB Peristaltic Pump Modules
  • QB Pressure Sensor Module
  • Custom 3D-printed perfusion chamber
  • Fluorescence-based imaging system
  • QB Control

The outcome

QB Systems enabled the research team to establish a robust perfusion platform. This solution acts now as a reliable experimental foundation, allowing the team to shift their focus toward refining biological models and analytical methods rather than managing manual fluid control challenges. By bridging the gap between hardware and research, the solution enabled stable conditions and reproducible results.

  • Stable Perfusion
  • Reproducibility
  • Quantitative Analysis
  • Reduced Variability

What we implemented

  • Modular Architecture Enabling future expansion and adaptation to evolving research needs.
  • Precise Flow Control Stable long-term performance with integrated pressure monitoring.
  • Remote Connectivity Enabling diagnostics, software updates, and technical support via VPN.
Paweł Godawa
Our goal was to make QB Systems disappear into the background of the experiment. The researchers should focus on nanoparticle behavior and data analysis - not on stabilizing flow conditions or troubleshooting hardware.
Paweł Godawa — Service Delivery Manager at A4BEE

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