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NanOX Recovery Box prototype

NanoGroup S.A. is a Polish biotechnology company developing innovative medical technologies, particularly in transplantology.

Industry

Biotech/Medtech

Scope

Hardware, Firmware, Software

Timeframe

Approximately 4 months

Technology

  • A4BEE CoreBoard® and HAT (Hardware Attached on Top)
  • C++ and NodeJS
  • Uninterruptible power supply
  • Digital gas mass flow controller
  • Heat pump for cooling and heating

4

months

8

developers

2

IT Engineers

The client

NanoGroup S.A. is a Polish biotechnology company developing innovative medical technologies, particularly in transplantology . We combine breakthrough solutions in nanotechnology with a unique approach to risk management . We collaborate with leading research and medical institutions, such as the Institute of Animal Physiology and Nutrition of the Polish Academy of Sciences and the Medical University of Warsaw . Our technologies, protected by global patents , have the potential to revolutionize medicine .

Business needs

The NanOX Recovery Box prototype, developed by NanoGroup and A4BEE, is set for further testing and refinement to meet regulatory certification standards for medical devices. The device is designed to revolutionize the storage and transportation of organs for transplantation. Its successful development and commercialization will solve critical challenges in organ storage and contribute to NanoGroup’s mission to advance nanotechnology in healthcare.

The challenge

  • 01

    Regulatory Compliance Ensuring the device meets medical device certification standards.

  • 02

    Technology Optimization Refining the prototype to maintain critical organ preservation parameters.

  • 03

    Testing & Validation Conducting successful operational and animal studies to confirm effectiveness.

  • 04

    Market Adoption Gaining acceptance and integrating the device into transplant protocols.

  • 05

    Collaboration Continuing partnerships with experts and institutions for development.

Our solution

In just 4 months, A4BEE delivered a functional prototype that met all technical requirements.

  1. Regulatory Compliance

    2 hours working time on the battery:

  2. Technology Optimization

    Separated wet and dry area:

  3. Testing & Validation

    Automatic regulation:

  4. Market Adoption

    Syringe pumps:

  5. Collaboration

    User Interface:

Technology used

  • A4BEE CoreBoard® and HAT (Hardware Attached on Top)
  • C++ and NodeJS
  • Uninterruptible power supply
  • Digital gas mass flow controller
  • Heat pump for cooling and heating

The outcome

Thanks to many projects for various clients we have high experience in Operational Technology, Internet of Things, pharma and biotech which are important for delivering projects like this one. Due to this background we were able to rethink crucial functionalities, used components and form of the device and come up with some improvements. One of the most helpful things were workshops with clinicians and perfusionists, people who will be the end users of the device, and gathering their perspective for a device like that one. The result from those meetings, many brainstorming sessions and hours during the development is Mobile Device able to automatic organ perfusion with separated areas and wireless connection. The created robust system and device allows for:

  • Uninterrupted 12h perfusion process of the kidney
  • Confirm the ability to manufacture such a completed device
  • Gather most important facts and information during the process from clinicians - the final users
  • Test cooling and heating system based on heat pump
Maciej Gaik
The NanoSanguis team contributed their expertise in perfusion and the optimal conditions required to sustain the viability of organs such as the kidneys, liver, and heart. Meanwhile, we at A4BEE brought in our specialized proficiency in cutting-edge technology. Leveraging our extensive experience from numerous projects across diverse industries—including Operational Technology, the Internet of Things, pharmaceuticals, and biotechnology—we were well-equipped to execute a project of this complexity. This strong foundation enabled us to reevaluate key functionalities, optimize component selection, refine the device’s design, and introduce critical enhancements. We relied solely on the knowledge transferred from NanoSanguis' prototypes at the project's inception. We have successfully developed a fully operational body simulator that is poised for upcoming NanOX fluid experiments.
Maciej Gaik — R&D Lead Engineer

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